Search flights from Santo Domingo (SDQ) to Panama City (PTY)
Book your plane tickets from Santo Domingo to Panama City with ease
Cheapest flights to Panama City
The cheapest flights available in the next 60 days – prices are updated regularly
Flying from Santo Domingo to Panama City: things to know
The most popular route is from Las Americas Airport in Santo Domingo to Tocumen International Airport in Panama City. On average this flight takes 3 hours 47 minutes one way and costs US$607 for the round trip.
Most popular route | Las Americas Airport (SDQ) to Tocumen International Airport (PTY) |
|---|---|
Average flight time | 3 hours 47 minutes |
Average round-trip price | US$607 |
Fly from Santo Domingo to Panama City | 4 airlines |
Reasons to book flights with Booking.com

Great selection
Easily compare flights, airlines and prices – all in one place

No hidden fees
Always know exactly what you’re paying for

Flexibility
Use our flexible plane ticket option to change your dates if needed
Flexible plane ticket options are available for an additional cost on selected airfares
Airlines that fly from Santo Domingo to Panama City
Airline options may vary according to recently booked flights and your search terms
Copa Airlines
Avianca
Spirit Airlines
Frequently asked questions
Fly to more destinations from Santo Domingo
MadridSpain
New YorkUnited States
Mexico CityMexico
MiamiUnited States
ZürichSwitzerland
Fort LauderdaleUnited States
MilanItaly
CancúnMexico
BogotáColombia
BarcelonaSpain
OrlandoUnited States
MedellínColombia
ParisFrance
BostonUnited States
RomeItaly
LondonUnited Kingdom
AmsterdamNetherlands
San JuanPuerto Rico
Sao PauloBrazil
Frankfurt/MainGermany
San JoséCosta Rica
MunichGermany
Cartagena de IndiasColombia
KingstonJamaica
Pointe-à-PitreGuadeloupe
VeniceItaly
PhiladelphiaUnited States
